Aciclovir is a pharmacologically inactive substance. After penetration into cells which are infected with herpes simplex virus types I and (HSV I & HSV II) or varicella-zoster virus (VSV), aciclovir is converted into a virostatic agent. The conversion of aciclovir is catalysed by viral HSV- or VZV- thymidine kinase. Human thymidine kinase does not use aciclovir effectively as a substrate, hence the toxicity to mammalian host cells is low. People who suffer from cold sores can often tellwhen they are about to get a cold sore by a tinglingor itching sensation. Lipsore 5% w/w Creamshould be used at this tingling stage or just afterskin bl isters appear. You should apply Lipsore 5% w/w Cream to theinfected area 5 times each day, at intervals of about4 hours, nighttime application can be omitted. Also contains: stearoyl macrogolglycerides, dimeticone, cetyl alcohol, liquid paraffin, white soft paraffin, propylee glycol and purified water.

Vial containing 250 mg Lipsore 5% will be reconstituted with 50 ml infusion solution and vial containing 500 mg Lipsore 5% will be reconstituted with 100 ml infusion solution. Besides, Vial containing 1 gm Lipsore 5% will be reconstituted with 250 ml infusion solution. 10 ml of the infusion solution will be added to the vial containing 250 mg, 500 mg and 1 gm Lipsore 5%. Shake well and transfer the required amount of solution to the infusion container. The final concentration of Lipsore 5% will be not more than 5 mg/ml. This medicine is available without prescription. However, you still need to use Lipsore 5% w/w Creamcarefully to get the best results from it. By working with a variety of trusted Range Plus Partners, we’re able to offer our customers a wider selection of products. Dose adjustment of IV for patients with acute or chronic renal impairment, based on Creatinine Clearance, Cr Cl (mL/min/1.73 m2):

Lipsore 5%

Directions: Apply a thin film of cream to the affected area five times dily at intervals of approximately 4 hours during the day omitting the night time application for at least 4 days. Consult your doctor or pharmacist before using this product if you know your immune system is weakened. Do not use in the eyes or on genitals. If the symptoms persist, consult your doctor. FOR EXTERNAL USE ONLY. Always use Cold Sore Cream exactly as instructed in this leaflet. If you are not sure, ask your doctor or pharmacy. It is best to apply the product as soon as possible after the start of the infection. For application to the surface of the skin only: 1. Wash your hands thoroughly before use. 2. Apply a thin layer of the cream to the infected area and the skin immediately next to it, 5 times a day at intervals of about 4 hours. Take care not to rub the infected skin any more than you need to. 3. Wash your hands again to avoid spreading the infection. 4. Use the cream for up to 5 days. If the infection has not healed after this time, you can contionue to use it for a further 5 days. Recyclable

People with particularly severe recurrent herpes labialis should be encouraged to seek medical advice.

How to take tablets and liquid

Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment, 2nd edition (2007) ed. Schaefer, C., Peters, P. and Miller, R. Elsevier, London.

As the aciclovir plasma concentrations following topical application are below the limit of detection, no pharmacokinetic studies are available on topical aciclovir. Therefore, the following data is based on the data after oral or intravenous administration. Lipsore 5% w/w cream contains cetyl alcohol and propylene glycol which may cause local skin reactions (skin irritation and redness). The following convention has been used for the classification of undesirable effects in terms of frequency:-The reconstituted solution should be used within 12 hours. Refrigeration of reconstituted solution may result in the formation of a precipitate which will re-dissolve at room temperature. Advise patients to apply the cream to the lesion as near as possible to the start of infection. Treat recurrent episodes during the prodromal period or when lesions first appear.

If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines. By reporting side effects you can help provide more information on the safety of this medicine. 5. How to store Lipsore 5% w/w Cream Keep out of the sight and reach of children. A thin film of cream should be applied to the infected and immediately adjacent skin areas 5 times daily at 4-hour intervals during the day omitting the night time application. Tell your doctor or pharmacist before use ifyou are taking any regular medication on prescription or over the counter products. On the basis of continuous absorption the concentration increased as a function of time (higher drug concentrations being found 48 hours post-topical dose than 24 hours post-topical dose). Thus short dosing intervals appear rational for the special treatment of herpes simplex virus (HSV) infections.Also contains: Stearoyl Macrogolglycerides, Dimeticone, Cetyl Alcohol, Liquid Paraffin, White Soft Paraffin, Propylene Glycol and Purified Water. Lipsore 5% w/w Cream is used to treat cold sores of the lips and face caused by the herpes simplex virus.Aciclovir has been shown to speed up the healing ofcold sore blisters if it is used soon enough. 2. Before you use Lipsore 5% w/w Cream Keep Lipsore 5% w/w Cream in its original container and store at a temperature below 25°C but do notrefrigerate or freeze. 6. Further informationWhat the cream contains: Use dimethicone products on your lips. Dimethicone is a moisturizing agent that can treat peeling and irritation in dehydrated skin, and heal the issues that result in soreness. [3] X Expert Source Mohiba Tareen, MD This article was co-authored by Tu Anh Vu, DMD. Dr. Tu Anh Vu is a Board Certified Dentist and Owner of Tu's Dental, her private practice, in Brooklyn, New York. With over six years of clinical experience, Dr. Vu helps adults and kids of all ages get over their anxiety with dental phobia. Dr. Vu has conducted research related to finding the cure for Kaposi Sarcoma cancer and has presented her research at the Hinman Meeting in Memphis. She received her undergraduate degree from Bryn Mawr College and a DMD from the University of Pennsylvania School of Dental Medicine.