Then the treatment of either ice pack, menthol-based gel or placebo gel were applied to one thigh while the other thigh was used to control for the effects of rest.

The softness and quality of the Renova Sensitive pocket tissue, joined by a subtle menthol perfume to provide a pleasant feeling of freshness and well-being. decreased by 67% for all three treatments and contralateral legs across the time course with no differences between them ( Figure 5B). This increased cutaneous flow occurs through activation of TRMP8 receptors in the vascular cells, 12, 13 which in turn increase Nitric Oxide production from the endothelial cells resulting in localized vasodilation. mm diameter), containing sterilized temperature probes; these contain small thermocouple probes have very low thermal inertia for a fast response and are insulated by a thin polymer layer so the surrounding environment cannot alter the measurement.The grid was then removed whereupon the gel was gently massaged using a stroking technique grade 1 20 into the skin for 10 minutes.

Recently, a systematic review 33 examined the topical analgesic clinical effectiveness of menthol Biofreeze ?However, these studies applied menthol to the upper arm 19, 26 and the upper leg (anterior and posterior) 25 and took blood flow measurements from brachial and popliteal arteries respectively; whereas the authors took their measurements from the femoral artery which is larger and deeper located than brachial and popliteal arteries, 27 therefore the relative effects of menthol gel application are likely to be less. For the ice treatment two plastic bags containing ice were secured to the marked anterior thigh portion, on top of a dry paper towel for 10 minutes. The tissues are perfumed with a delicate menthol scent, which helps to breathe more easily during a cold and thus provide a pleasant feeling of freshness and well-being. Cutaneous blood flow did increase but arterial blood flow remained unchanged, in comparison to ice, placebo gel and control leg, therefore the authors are unsure regarding the source of the increased blood flow.