With timing, any item seen briefly during the rapid reroll process can be picked up, similar to acquiring items from Glitched Crown.

There is a 1% chance to spawn one of the following items instead: Mom's Underwear, Mom's Heels, Mom's Lipstick, Mom's Bra, Mom's Pad, Mom's Eyeshadow, Mom's Contacts, Mom's Wig, Mom's Perfume or Mom's Pearls.

Excerpts and links may be used, provided that full and clear credit is given to the FabFree author and Fabulously Free in SL with appropriate and specific direction to the original content. While the Machine takes red hearts before Soul Hearts or Black Hearts, Using a Blood Donation Machine will trigger Scapular once Isaac is at half a heart.

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Once a Blood Donation Machine has given IV Bag, future Blood Donation Machines will never pay out with it again for the rest of the run unless Blood Bag has not been unlocked yet. For debugging purposes, an init seed that spawns a slot machine that pays out a Dollar on the first attempt is 1236239571. Fortune Telling Machines appear naturally in Arcades, Secret Rooms, Super Secret Rooms, and other room layouts, and can be summoned using the X - Wheel of Fortune tarot card.

Blood Donation Machines may fail to pay out when used as Keeper or Tainted Keeper, preventing abuse. Every donation has a chance of causing the Blood Donation Machine to explode, giving either a Blood Bag or an IV Bag. When Isaac's health is at half a heart (or a full heart in Womb and beyond), the machine will drain Soul Hearts and Black Hearts instead.Repeating this process after every Scapular activation allows Isaac to collect coins from the Blood Donation Machine until it breaks. There is a 25% chance for the Machine to pay out, so the probability of the machine paying out after at most N {\displaystyle N} tries is 1 − ( 3 / 4 ) N {\displaystyle 1-(3/4) Saving and quitting in the middle of the reroll process will cause the items to stop rerolling upon re-entering the game. When blown up in the Dark Room or Chest, it will drop a collectible from the Treasure Room item pool, much like normal and golden Chests. If Daemon's Tail is held, there is an 80% chance to prevent this grouping from being chosen; if prevented, another pickup grouping will be chosen instead.