I researched online and believe God led me to several medical articles stating that Thiamine deficiency during the refeeding phase could cause renal tubular dysfunction resulting in electrolyte losses via the kidneys. So electrolyte values during the refeeding phase after fasting could be Refeeding Syndrome’s intracellular losses -OR- urinary losses from Thiamine Deficiency. But the b12 was the only thing that made me feel any better, even though the constant state of apathy I lived in. I had no energy and no strength whatsoever. http://www.casereports.in/articles/6/3/Thiamine-Therapy-and-Refeeding-Syndrome-in-Extremely-Low-Birth-Weight-Infants.html I guess that that is the case for me, going from catabolic to anabolic, since I finally started to gain a little bit weight. http://www.biolab.co.uk/index.php/cmsid__biolab_test/Vitamin_B1_(Thiamine)_-_transketolase_activity

We are trying to fix these deficiencies, but we are struggling. I started Lipothiamine 2 weeks ago, because Thiamine HCl and sublingual cocarboxylase didn’t help my B1 deficiency. It’s been a difficult start. Increased energy, slight POTS and IBS reduction; however, restlessness and anxiety has increased significantly. Also, increased pins and needles, and poor sleep. Maybe this is the paradox that is mentioned in several articles. This paradox is incredibly unpleasant and I understand why people stop treatment. I took massive amounts of b12 supplements and ate beef liver and salmon everyday. The beef liver was the major thing that would make me feel okay, and I didn’t understand why. I’d tried b1 supplements before, but these were all the water soluble form. I would love to know what caused my health problems, but my tests have mostly been normal except for Graves’ disease. Even my genome looks okay, with no problems on the thiamine or cobalamin transporter genes. It makes me a bit uneasy to keep my B12 level so high, so I’d really like to understand why I need it.

What I really wonder is, what your current regimen is regarding supplements/vitamins, but it is up to you, if you wish to answer this or not. A similar chemical, also a thiamine open-ring disulfide derivative, sulbutiamine, is available as a powder through several online venders (like Nootropics Depot, to name one). I don’t know what the equivalent dosage to TTFD would be, however. Because he’s young, I expect he won’t swallow capsules well. From your posts, I see that Lipothiamine is enteric coated and preferred but that Allithiamine can be divided if necessary?

I suffered a disc rupture (L5/s1) needing surgery 27.12.17 as it had sequestered. Ouch!! Pain relief was instant but I didn’t make a good recovery with on going burning stinging nerve pain. I used to be a heavy weekend drinker, have had high stress jobs (sister in a NICU in the UK) and life stress losing both parents before they aged 70, mum to breast cancer aged 62 and dad to general ill health resulting in an above knee amputation. In the 8 year period they passed I also had a baby. I am wondering if there’s a genetic component to my probable thiamine deficiency? Thomford N.E., Senthebane D.A., Rowe A., Munro D., Seele P., Maroyi A., Dzobo K. Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery. Int. J. Mol. Sci. 2018;19:1578. doi: 10.3390/ijms19061578.An interesting topic would be the quality of lab testing available. I have taken Genova OAT and Great Plains labs in the past, I took the Spectrecell lab most recently which was the one that measured my B1 and aspartate deficiency and low glutathione, big markers in my case.