Are taking colestyramine which is used to lower blood cholesterol, or metoclopramide or domperidone for nausea or vomiting. Caffeine is a mild stimulant that helps reduce fatigue. Caffeine is also thought to enhance the painkilling effect of paracetamol. The antidiabetic medicines exenatide, lixisenatide and liraglutide may slow down the absorption of paracetamol into the bloodstream, so it might take longer to work if you're using one of these medicines to treat your diabetes. Ask your pharmacist for more advice. Paracetamol is generally considered safe for use during pregnancy. However, caffeine consumption should be limited in pregnancy, and phenylephrine has blood vessel constricting effects that could restrict blood supply to the placenta, or cause problems for women with a history of pre-eclampsia. As a result, this medicine is not usually recommended for use by women who are pregnant. Seek further medical advice from your doctor, pharmacist or midwife.

There is also some evidence that a spoonful of honey dissolved in warm water is actually more effective than medicated products for reducing the frequency and severity of a cough. Find out more about which painkiller to choose for different types of aches and pains in our full painkillers guideLiver damage is possible in adults who have taken 10g or more of paracetamol. Ingestion of 5g or more of paracetamol may lead to liver damage if the patient has risk factors (see below).

Although paracetamol is considered safe for use during breastfeeding, caffeine passes into breast milk and can cause irritability and poor sleeping pattern in a nursing baby. It is not known if phenylephrine passes into breast milk, or its effect on a nursing infant. However, when taken by mouth, decongestants such as phenylephrine can temporarily decrease the production of breast milk with just one or two doses. For this reason, this medicine is best avoided by mothers who are breastfeeding. Ask your doctor or pharmacist for further advice. It's fine to take Beechams flu plus caplets with plain ibuprofen or aspirin (assuming these are appropriate for you). However, don't take them with co-codamol, co-dydramol or Tramacet because these contain paracetamol. Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect. Caffeine can increase the elimination of lithium from the body. If taken concomitantly, it is recommended to reduce or moderate the intake of caffeine.

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Do not take with any other paracetamol containing products or with any other flu, cold or decongestant products.

No specific antidote is available, but supportive measures such as beta adrenoceptor antagonists to reverse the cardiotoxic effects may be used. The body produces prostaglandins in response to injury and certain diseases. One of the effects of prostaglandins is to sensitise nerve endings, causing pain (presumably to prevent us from causing further harm to the area). As paracetamol reduces the production of these nerve sensitising prostaglandins it is thought it may increase our pain threshold, so that although the cause of the pain remains, we can feel it less. For the cheapest option, seek out own-brand or generic painkillers. Supermarkets and discount stores are often cheapest, and branded versions can cost nearly five times as much. Treatment with activated charcoal should be considered if the overdose has been taken within 1 hour. Plasma paracetamol concentration should be measured at 4 hours or later after ingestion (earlier concentrations are unreliable). Treatment with N-acetylcysteine may be used up to 24 hours after ingestion of paracetamol, however, the maximum protective effect is obtained up to 8 hours post-ingestion. The effectiveness of the antidote declines sharply after this time. If required the patient should be given intravenous N-acetylcysteine, in line with the established dosage schedule. If vomiting is not a problem, oral methionine may be a suitable alternative for remote areas, outside hospital. Management of patients who present with serious hepatic dysfunction beyond 24h from ingestion should be discussed with the NPIS or a liver unit. Acute pancreatitis has been observed, usually with hepatic dysfunction and liver toxicity. Allergic reactions such as a rash or itching. Stop using this medicine and get medical advice if you think you've had an allergic reaction to it.Here's everything you need to know about Beechams flu caplets, including how they work, who shouldn't use them and the potential side effects: How do Beechams flu plus caplets work? This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately. Use with caution in Paracetamol is thought to relieve pain by reducing the production of prostaglandins in the brain and spinal cord. It works to bring down a fever by affecting an area of the brain that regulates our body temperature (the hypothalamic heat-regulating center). This stops you feeling hot or shivery.