Szulinska M, Loniewski I, van Hemert S, Sobieska M, Bogdanski P. Dose-Dependent Effects of Multispecies Probiotic Supplementation on the Lipopolysaccharide (LPS) Level and Cardiometabolic Profile in Obese Postmenopausal Women: A 12-Week Randomized Clinical Trial. Nutrients. 2018 Jun 15;10(6):773. doi: 10.3390/nu10060773. kapsułka zawierabakterii ≥2.5 x 10 9 CFU/g żywych szczepów bakterii: Bifidobacterium lactis W52, Lactobacillus brevis W63, Lactobacillus casei W56, Lactococcus lactis W19, Lactococcus lactis W58, Lactobacillus acidophilus W37, Bifidobacterium bifidum W23, Bifidobacterium lactis W51, Lactobacillus salivarius W24. At the endpoint, FSH level has increased significantly concerning the baseline after the probiotic intake (31.91 vs. 42.00 mIU/ml; p < 0.009). Also, in the placebo group, a strong trend to elevate FSH was observed (22.31 vs. 41.99 mIU/ml; p = 0.055). Body mass has crucially decreased in reference to the baseline in both groups (PRO: 27.90 vs. 26.30 kg/m2, p<0.001; PBO: 25.90 to 24.60 kg/m2, p<0.001). Probiotics have already been shown to modify the intestinal microbiota and their usage may exert a beneficial effect on the oxidative stress parameters. Informacje dodatkowe to dodatkowe szczegóły dotyczące produktu. Pomagają w lepszym wyborze odpowiedniego produktu, który spełni nasze oczekiwania.

de Roos NM, Giezenaar CG, Rovers JM, Witteman BJ, Smits MG, van Hemert S. The effects of the multispecies probiotic mixture Ecologic(R)Barrier on migraine: results of an open-label pilot study. Benef Microbes. 2015;6(5):641-6. doi: 10.3920/BM2015.0003. Epub 2015 Apr 22. In this randomized, double-blind, and placebo-controlled study, 48 perimenopausal and postmenopausal women received multispecies probiotic Sanprobi Barrier in a dose of 2.5 × 109 (CFU) for five weeks. Dietary guidelines were introduced in both groups simultaneously (~1800 kcal/per day, whole grain, no-wheat meals). The study aimed to assess the variations in follicle-stimulating hormone (FSH), estradiol (E2), cortisol (as the hypothalamic-pituitary-ovarian axis hormone), and the body mass during the intervention.Thomas DT, Erdman KA, Burke LM. Position of the Academy of Nutrition and Dietetics, Dietitians of Canada, and the American College of Sports Medicine: Nutrition and Athletic Performance. J Acad Nutr Diet. 2016 Mar;116(3):501-528. doi: 10.1016/j.jand.2015.12.006. Erratum In: J Acad Nutr Diet. 2017 Jan;117(1):146. Twice (during the initial and final stages) the following measurements were taken: complete blood count with smear, fasting glucose, total cholesterol, HDL, LDL and triglycerides, sodium, iron, potassium, magnesium, serum calcium, determination C-reactive protein (CRP) concentrations. Elbere I, Kalnina I, Silamikelis I, Konrade I, Zaharenko L, Sekace K, Radovica-Spalvina I, Fridmanis D, Gudra D, Pirags V, Klovins J. Association of metformin administration with gut microbiome dysbiosis in healthy volunteers. PLoS One. 2018 Sep 27;13(9):e0204317. doi: 10.1371/journal.pone.0204317. eCollection 2018. Calprotectin has been widely used in contemporary clinical practice to monitor inflammation of the gut mucosa. Participants were informed that the cardiorespiratory fitness test should take place for a minimum of 2 weeks after intense physical effort (marathon, ultramarathon).

Inflammatory state will be assessed by measurement of blood C-reactive protein (CRP) as well as blood and stool calprotectin.

Medical Conditions

Elevation of ALT and aspartate aminotransferase (AST) activity in the blood serum, three times above the reference value kapsułka zawiera łącznie 2,5×10 9 CFU/g bakterii Bifidobacterium lactis W51, Lactobacillus brevis W63, Lactobacillus acidophilus W22, Bifidobacterium bifidum W23 i Lactococcus lactis W58; Probiotics, defined as "live microorganisms, that when administered in adequate amounts, confer a health benefit on the host", may have the potential to modulate the gut bacterial composition.

Physically active people should take special care about the tightness of their intestines. First of all, they are especially prone to the dysfunctions of the intestinal barrier due to the fact that each training session is a considerable stress factor, disturbing eubiosis (bacterial balance) of the intestines. Secondly, probiotic therapy allows to avoid digestive discomfort, often experienced during training. Thirdly, the tightness of the intestinal barrier influences the functioning of brain-gut axis, which is reflected in the functionality of the nervous system, which mainly decides about our effort and motor abilities. Participants will be asked to collect stool samples after overnight fasting to avoid the effect of food consumption on short-chain fatty acid synthesis. Each participant will receive detailed instructions describing the method for material collection. A plastic holder will be used to collect faeces into a sterilized screw-capped collection container. Participants will be asked to store the sample in a fridge and deliver the sample up to 24h after collection to the clinic. The samples will be preserved in 2mL Eppendorf tubes containing 600μL DNA/RNA later solution (Zymo Research, Freiburg, Germany) to prevent the degradation processes and will be frozen at −80°C until the beginning of the microbiota analyses. Visit 3 - month 1 (4 weeks ± 3 days from the visit 2) Gastrointestinal symptoms questionnaire administration. The intestinal barrier creates a protective wall between the human body and the outside world. Its most important task is the proper selection and absorption of nutrients beneficial for health, protection against toxins and their elimination from the body, preventing the entry of pathogens from the gastrointestinal tract into the body. In addition, the intestinal barrier performs important physiological functions in the human body, therefore the disruption of its structure can lead to increased permeability, promote the overloading of the immune and nervous system.Three people from the G2 control group (product B) did not participate in the final stage of the study (W2) due to injury (2 people) and without providing a specific reason (1 person). You may also open the capsule and sprinkle the probiotic into a cold drink or cold soft food, following the same directions for the oral powder. Videbaek S, Bueno AM, Nielsen RO, Rasmussen S. Incidence of Running-Related Injuries Per 1000 h of running in Different Types of Runners: A Systematic Review and Meta-Analysis. Sports Med. 2015 Jul;45(7):1017-26. doi: 10.1007/s40279-015-0333-8. Snaprobi Barrier is a multi-strain probiotic that contains a unique composition of eight carefully selected probiotic strains that maintain and support the intestinal barrier. None of the competitors had an implanted pacemaker, which is an absolute exclusion criterion in the study of body composition analysis by electrical bioimpedance.

Wskazanie to parametr, który określa w jakim celu dany lek bądź suplement diety może być stosowany. Może to być np. uzupełnienie diety w składniki odżywcze, wsparcie organizmu w stanach niedoboru, poprawa zdrowia i samopoczucia. Wskazanie produktu jest ważne, ponieważ pozwala dobrać lek bądź suplement diety do indywidualnych potrzeb Użytkownika. Sanprobi Barrier is an advanced probiotic preparation constituting a response to the needs of a modern human being. It provides the complex of eight bacterial strains with a key meaning for the tightness of intestinal barrier. At certain visits patients will undergo the tests measuring the intestinal permeability (blood and stool zonulin immunoenzymatic tests). ABriones M., Touyz R.M. Oxidative stress, and hypertension: Current concepts. Curr. Hypertens. Rep. 2010;12:135–142. doi: 10.1007/s11906-010-0100-z. kapsułka zawiera łącznie ≥2,5×10 9 CFU/g żywych szczepów bakterii Bifidobacterium lactis W52, Lactobacillus brevis W63, Lactobacillus casei W56, Lactococcus lactis W19, Lactococcus lactis W58, Lactobacillus acidophilus W37, Bifidobacterium bifidum W23, Bifidobacterium lactis W51 i Lactobacillus salivarius W24,Skrobia kukurydziana, maltodekstryny, białko roślinne, Bifidobacterium Iactis W52; Lactobacillus brevis W63; Lactobacillus casei W56; Lactococcus lactis W19; Lactococcus lactis W58; Lactobacillus acidophilus W37; Bifidobacterium bifidum W23; Lactobacillus salivarius W24; otoczkakapsułki: hydroksypropylometyloceluloza. Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC, Sanders ME. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):506-14. doi: 10.1038/nrgastro.2014.66. Epub 2014 Jun 10.